I have an eee 1000 netbook running Ubuntu Jaunty netbook remix. Installing and configuring Skype was pretty simple:

Add the Medibuntu repository:

sudo wget http://www.medibuntu.org/sources.list.d/jaunty.list --output-document=/etc/apt/sources.list.d/medibuntu.list
sudo apt-get update
sudo apt-get install medibuntu-keyring
sudo apt-get update

Install skype:

sudo aptitude install skype

Video worked out of the box. To configure sound, got to Options -> Sound Devices. Set:
Sound In: HDA Intel (hw:Intel,0)
Sound Out: Pulse
Ringing: Pulse

Related posts:

1. Pidgin OSD pop ups in Ubuntu Jaunty
2. Tethered Blackberry Modem on Ubuntu Karmic
3. In Ubuntu Jaunty, shift, ctrl,alt, and caps lock buttons stop working
4. Rip and convert to MP3 files in Debian Lenny
5. Convert High-Def MKV to play on xbox 360 using Linux